This project builds infrastructure that encourages data-driven discovery from distributed, fragmented datasets without requiring movement of massive amounts of data and without exposing sensitive raw datasets to end users. A Virtual Information-Fabric Infrastructure (VIFI) is created, allowing scientists to search, access, manipulate, and evaluate fragmented, distributed data in the information ‘fabric’ (the infrastructure to facilitate data sharing) without directly accessing or moving large amounts of data. The system addresses the challenges of coordinating loosely federated infrastructure, distributed data management, security and privacy.