Astronomical data are gathered through a very large number of heterogeneous techniques and stored in very diversified and often incompatible data repositories. Moreover in the e-science environment, it is needed to integrate services across distributed, heterogeneous, dynamic arcsecvirtual organizations arcsec formed by different resources within a single enterprise and/or external resource sharing and service provider relationships. The DAME/VONeural project, run jointly by the University Federico II, INAF (National Institute of Astrophysics) Astronomical Observatories of Napoli and the California Institute of Technology, aims at creating a single, sustainable, distributed e-infrastructure for data mining and exploration in massive data sets, to be offered to the astronomical (but not only) community as a web application. The framework makes use of distributed computing environments (e.g. S.Co.P.E.) and matches the international IVOA standards and requirements. The integration process is technically challenging due to the need of achieving a specific quality of service when running on top of different native platforms. In these terms, the result of the DAME/VO-Neural project effort will be a service-oriented architecture, obtained by using appropriate standards and incorporating Grid paradigms and restful Web services frameworks where needed, that will have as main target the integration of interdisciplinary distributed systems within and across organizational domains.